Saileta Prabhu : rechercher sur Z-Library

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1

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

Deng, Rong, Jin, Feng, Prabhu, Saileta, Iyer, Suhasini

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2012

Langue:

english

Fichier:

PDF, 514 KB

english, 2012

2

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

Gadkar, Kapil, Yadav, Daniela Bumbaca, Zuchero, Joy Yu, Couch, Jessica A., Kanodia, Jitendra, Kenrick, Margaret K., Atwal, Jasvinder K., Dennis, Mark S., Prabhu, Saileta, Watts, Ryan J., Joseph, Sean

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2016

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2016

3

Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies

Wendy S. Putnam, Saileta Prabhu, Yanan Zheng, Meena Subramanyam, Yow-Ming C. Wang

Journal:

Trends in Biotechnology

Année:

2010

Langue:

english

Fichier:

PDF, 195 KB

english, 2010

4

Vascular Physiology and Protein Disposition in a Preclinical Model of Neurodegeneration

Boswell, C. Andrew, Mundo, Eduardo E., Johnstone, Bernadette, Ulufatu, Sheila, Schweiger, Michelle G., Bumbaca, Daniela, Fielder, Paul J., Prabhu, Saileta, Khawli, Leslie A.

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 1007 KB

english, 2013

5

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

Baumann, Andreas, Tuerck, Dietrich, Prabhu, Saileta, Dickmann, Leslie, Sims, Jennifer

Journal:

Drug Discovery Today

Année:

2014

Langue:

english

Fichier:

PDF, 532 KB

english, 2014

6

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L., Fielder, Paul J., Prabhu, Saileta

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2011

7

An Improved Method for the Determination of Green and Black Tea Polyphenols in Biomatrices by High-Performance Liquid Chromatography with Coulometric Array Detection

Mao-Jung Lee, Saileta Prabhu, Xiaofeng Meng, Chuan Li, Chung S. Yang

Journal:

Analytical Biochemistry

Année:

2000

Langue:

english

Fichier:

PDF, 78 KB

english, 2000

8

Determination of 2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and Its Metabolite 2-Hydroxyamino-PhIP by Liquid Chromatography/Electrospray Ionization–Ion Trap Mass Spectrometry

Saileta Prabhu, Mao-Jung Lee, Wen-Yu Hu, Bozena Winnik, Ill Yang, Brian Buckley, Jun-Yan Hong

Journal:

Analytical Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 91 KB

english, 2001

9

Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Min Zhong, Emily J. Hanan, Wang Shen, Minna Bui, Michelle R. Arkin, Kenneth J. Barr, Marc J. Evanchik, Ute Hoch, Jennifer Hyde, Jose R. Martell, Johan D. Oslob, Kumar Paulvannan, Saileta Prabhu, Jeffr

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 349 KB

english, 2011

10

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

Siamak Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny, Jason S. Halladay, Anthony Y. H. Lu

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Année:

2011

Langue:

english

Fichier:

PDF, 357 KB

english, 2011

11

Identification of glutathione conjugates of troglitazone in human hepatocytes

Saileta Prabhu, Andrew Fackett, Scott Lloyd, Holly A McClellan, Chris M Terrell, Paul M Silber, Albert P Li

Journal:

Chemico-Biological Interactions

Année:

2002

Langue:

english

Fichier:

PDF, 477 KB

english, 2002

12

Enhancing antibody uptake in brain to target BACE1

Jasi Atwal, Joy Yu, Yin Zhang, Yongmei Chen, Cecilia Chiu, William Meilandt, Kimberly Scearce-Levie, Yanmei Lu, Margaret Kenrick, Saileta Prabhu, Yan Wu, Mark Dennis, Ryan Watts

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 58 KB

english, 2012

13

Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology

Prabhu, Saileta, Boswell, C Andrew, Leipold, Douglas, Khawli, Leslie A, Li, Dongwei, Lu, Dan, Theil, Frank-Peter, Joshi, Amita, Lum, Bert L

Journal:

Therapeutic Delivery

Année:

2011

Langue:

english

Fichier:

PDF, 2.79 MB

english, 2011

14

Drug Delivery across the Blood–Brain Barrier

Khawli, Leslie A., Prabhu, Saileta

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 142 KB

english, 2013

15

Structural Identification of Two Metabolites of Catechins and Their Kinetics in Human Urine and Blood after Tea Ingestion

Li, Chuan, Lee, Mao-Jung, Sheng, Shuqun, Meng, Xiaofeng, Prabhu, Saileta, Winnik, Bozena, Huang, Baoming, Chung, Jee Y., Yan, Shunqi, Ho, Chi-Tang, Yang, Chung S.

Journal:

Chemical Research in Toxicology

Année:

2000

Langue:

english

Fichier:

PDF, 210 KB

english, 2000

16

Comparative Physiology of Mice and Rats: Radiometric Measurement of Vascular Parameters in Rodent Tissues

Boswell, C. Andrew, Mundo, Eduardo E., Ulufatu, Sheila, Bumbaca, Daniela, Cahaya, Hendry S., Majidy, Nicholas, Van Hoy, Marjie, Schweiger, Michelle G., Fielder, Paul J., Prabhu, Saileta, Khawli, Lesli

Journal:

Molecular Pharmaceutics

Année:

2014

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2014

17

Anti-CD22-MCC-DM1 and MC-MMAF Conjugates: Impact of Assay Format on Pharmacokinetic Parameters Determination

Stephan, Jean-Philippe, Chan, Pamela, Lee, Chien, Nelson, Christopher, Elliott, James Michael, Bechtel, Charity, Raab, Helga, Xie, David, Akutagawa, Jon, Baudys, Jakub, Saad, Ola, Prabhu, Saileta, Won

Journal:

Bioconjugate Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 570 KB

english, 2008

18

Quantitative cumulative biodistribution of antibodies in mice

Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 754 KB

english, 2014

19

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

Lu, Dan, Jin, Jin Yan, Girish, Sandhya, Agarwal, Priya, Li, Dongwei, Prabhu, Saileta, Dere, Randall C., Saad, Ola M., Nazzal, Denise, Koppada, Neelima, Ramanujan, Saroja, Ng, Chee M.

Journal:

Pharmaceutical Research

Année:

2015

Langue:

english

Fichier:

PDF, 882 KB

english, 2015

20

Subcutaneous bioavailability of therapeutic antibodies as a function  of FcRn binding affinity in mice

Deng, Rong, Meng, Y. Gloria, Hoyte, Kwame, Lutman, Jeff, Lu, Yanmei, Iyer, Suhasini, DeForge, Laura E, Theil, Frank-Peter, Fielder, Paul J., Prabhu, Saileta

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 951 KB

english, 2012

21

A strategy for risk mitigation of antibodies with fast clearance

Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2012

22

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies

Mortensen, Deborah L., Prabhu, Saileta, Stefanich, Eric G., Kadkhodayan-Fischer, Saloumeh, Gelzleichter, Thomas R., Baker, Dana, Jiang, Jenny, Wallace, Kristin, Iyer, Suhasini, Fielder, Paul J., Putna

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2012

23

Prevention of carcinogenesis by tea polyphenols* †

Yang, Chung S., Prabhu, Saileta, Landau, Janelle

Journal:

Drug Metabolism Reviews

Année:

2001

Langue:

english

Fichier:

PDF, 389 KB

english, 2001

24

Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: Formation of different metabolites and individual variability

Lee, Mao Jung, Maliakal, Pius, Chen, Laishun, Meng, Xiaofeng, Bondoc, Flordeliza Y., Prabhu, Saileta, Lambert, George, Mohr, Sandra, Yang, Chung S.

Journal:

Cancer Epidemiology Biomarkers & Prevention

Année:

2002

Langue:

english

Fichier:

PDF, 243 KB

english, 2002

25

Introduction to the theme ‘technology – translational pharmacology’

Prabhu, Saileta

Journal:

Drug Discovery Today: Technologies

Année:

2016

Langue:

english

Fichier:

PDF, 184 KB

english, 2016

26

Evaluation of Fluorophotometry to Assess the Vitreal Pharmacokinetics of Protein Therapeutics

Dickmann, Leslie J., Yip, Victor, Li, Cuiwen, Abundes, Juan, Maia, Mauricio, Young, Cynthia, Stainton, Shannon, Hass, Philip E., Joseph, Sean B., Prabhu, Saileta, Boswell, C. Andrew

Journal:

Investigative Opthalmology & Visual Science

Année:

2015

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2015

27

Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology

Mandikian, Danielle, Figueroa, Isabel, Oldendorp, Amy, Rafidi, Hanine, Ulufatu, Sheila, Schweiger, Michelle G., Couch, Jessica A., Dybdal, Noel, Joseph, Sean B., Prabhu, Saileta, Ferl, Gregory Z., Bos

Journal:

The AAPS Journal

Année:

2018

Langue:

english

Fichier:

PDF, 968 KB

english, 2018

28

Pharmacokinetic and pharmacodynamic considerations in the design of therapeutic antibodies

Leipold, Douglas, Prabhu, Saileta

Journal:

Clinical and Translational Science

Année:

2018

Langue:

english

Fichier:

PDF, 613 KB

english, 2018